Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Otx2  orthodenticle homeobox 2   (Synonyms: E130306E05Rik)
Results	Reference
1*	J:89361 Acampora D, Annino A, Puelles E, Alfano I, Tuorto F, Simeone A, OTX1 compensates for OTX2 requirement in regionalisation of anterior neuroectoderm. Gene Expr Patterns. 2003 Aug;3(4):497-501
1	J:47899 Acampora D, Avantaggiato V, Tuorto F, Barone P, Reichert H, Finkelstein R, Simeone A, Murine Otx1 and Drosophila otd genes share conserved genetic functions required in invertebrate and vertebrate brain development. Development. 1998 May;125(9):1691-702
1	J:43308 Acampora D, Avantaggiato V, Tuorto F, Simeone A, Genetic control of brain morphogenesis through Otx gene dosage requirement. Development. 1997 Sep;124(18):3639-50
1*	J:72726 Acampora D, Boyl PP, Signore M, Martinez-Barbera JP, Ilengo C, Puelles E, Annino A, Reichert H, Corte G, Simeone A, OTD/OTX2 functional equivalence depends on 5' and 3' UTR-mediated control of Otx2 mRNA for nucleo-cytoplasmic export and epiblast-restricted translation. Development. 2001 Dec;128(23):4801-13
1*	J:153562 Acampora D, Di Giovannantonio LG, Di Salvio M, Mancuso P, Simeone A, Selective inactivation of Otx2 mRNA isoforms reveals isoform-specific requirement for visceral endoderm anteriorization and head morphogenesis and highlights cell diversity in the visceral endoderm. Mech Dev. 2009 Oct;126(10):882-97
1*	J:32929 Avantaggiato V, Acampora D, Tuorto F, Simeone A, Retinoic acid induces stage-specific repatterning of the rostral central nervous system. Dev Biol. 1996 May 1;175(2):347-57
1*	J:118802 Blak AA, Naserke T, Saarimaki-Vire J, Peltopuro P, Giraldo-Velasquez M, Vogt Weisenhorn DM, Prakash N, Sendtner M, Partanen J, Wurst W, Fgfr2 and Fgfr3 are not required for patterning and maintenance of the midbrain and anterior hindbrain. Dev Biol. 2007 Mar 1;303(1):231-43
1*	J:71034 Boyl PP, Signore M, Acampora D, Martinez-Barbera JP, Ilengo C, Annino A, Corte G, Simeone A, Forebrain and midbrain development requires epiblast-restricted Otx2 translational control mediated by its 3' UTR. Development. 2001 Aug;128(15):2989-3000
1	J:57538 Broccoli V, Boncinelli E, Wurst W, The caudal limit of Otx2 expression positions the isthmic organizer. Nature. 1999 Sep 9;401(6749):164-8
1	J:176481 Brown A, Machan JT, Hayes L, Zervas M, Molecular organization and timing of Wnt1 expression define cohorts of midbrain dopamine neuron progenitors in vivo. J Comp Neurol. 2011 Oct 15;519(15):2978-3000
1	J:180898 Brown AS, Epstein DJ, Otic ablation of smoothened reveals direct and indirect requirements for Hedgehog signaling in inner ear development. Development. 2011 Sep;138(18):3967-76
1	J:155225 Castelo-Branco G, Andersson ER, Minina E, Sousa KM, Ribeiro D, Kokubu C, Imai K, Prakash N, Wurst W, Arenas E, Delayed dopaminergic neuron differentiation in Lrp6 mutant mice. Dev Dyn. 2009 Sep 30;239(1):211-221
1	J:266183 Cerrato V, Mercurio S, Leto K, Fuca E, Hoxha E, Bottes S, Pagin M, Milanese M, Ngan CY, Concina G, Ottolenghi S, Wei CL, Bonanno G, Pavesi G, Tempia F, Buffo A, Nicolis SK, Sox2 conditional mutation in mouse causes ataxic symptoms, cerebellar vermis hypoplasia, and postnatal defects of Bergmann glia. Glia. 2018 Sep;66(9):1929-1946
1	J:156733 Deng M, Pan L, Xie X, Gan L, Requirement for Lmo4 in the vestibular morphogenesis of mouse inner ear. Dev Biol. 2010 Feb 1;338(1):38-49
1*	J:206224 Dixit R, Tachibana N, Touahri Y, Zinyk D, Logan C, Schuurmans C, Gene expression is dynamically regulated in retinal progenitor cells prior to and during overt cellular differentiation. Gene Expr Patterns. 2014 Jan;14(1):42-54
1	J:108511 Griesel G, Treichel D, Collombat P, Krull J, Zembrzycki A, van den Akker WM, Gruss P, Simeone A, Mansouri A, Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border. Development. 2006 May;133(9):1779-87
1	J:210692 Hagglund AC, Berghard A, Carlsson L, Canonical Wnt/beta-catenin signalling is essential for optic cup formation. PLoS One. 2013;8(12):e81158
1	J:128377 Hatch EP, Noyes CA, Wang X, Wright TJ, Mansour SL, Fgf3 is required for dorsal patterning and morphogenesis of the inner ear epithelium. Development. 2007 Oct;134(20):3615-25
1	J:224836 Hoch RV, Lindtner S, Price JD, Rubenstein JL, OTX2 Transcription Factor Controls Regional Patterning within the Medial Ganglionic Eminence and Regional Identity of the Septum. Cell Rep. 2015 Jul 21;12(3):482-94
1	J:164582 Hurd EA, Poucher HK, Cheng K, Raphael Y, Martin DM, The ATP-dependent chromatin remodeling enzyme CHD7 regulates pro-neural gene expression and neurogenesis in the inner ear. Development. 2010 Sep;137(18):3139-50
1	J:112633 Jukkola T, Lahti L, Naserke T, Wurst W, Partanen J, FGF regulated gene-expression and neuronal differentiation in the developing midbrain-hindbrain region. Dev Biol. 2006 Sep 1;297(1):141-57
1	J:305429 Kaiser M, Wojahn I, Rudat C, Ludtke TH, Christoffels VM, Moon A, Kispert A, Trowe MO, Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse. Development. 2021 Apr 15;148(8):dev195651
1*	J:91011 Kurokawa D, Kiyonari H, Nakayama R, Kimura-Yoshida C, Matsuo I, Aizawa S, Regulation of Otx2 expression and its functions in mouse forebrain and midbrain. Development. 2004 Jul;131(14):3319-31
1	J:79431 Li JY, Lao Z, Joyner AL, Changing requirements for Gbx2 in development of the cerebellum and maintenance of the mid/hindbrain organizer. Neuron. 2002 Sep 26;36(1):31-43
1	J:98385 Li JY, Lao Z, Joyner AL, New regulatory interactions and cellular responses in the isthmic organizer region revealed by altering Gbx2 expression. Development. 2005 Apr;132(8):1971-81
1	J:98487 Lin Z, Cantos R, Patente M, Wu DK, Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signaling. Development. 2005 May;132(10):2309-18
1*	J:69855 Martinez-Morales JR, Signore M, Acampora D, Simeone A, Bovolenta P, Otx genes are required for tissue specification in the developing eye. Development. 2001 Jun;128(11):2019-30
1	J:29682 Matsuo I, Kuratani S, Kimura C, Takeda N, Aizawa S, Mouse Otx2 functions in the formation and patterning of rostral head. Genes Dev. 1995 Nov 1;9(21):2646-58
1	J:165012 Melloy PG, Kusnierczyk MK, Meyer RA, Lo CW, Desmond ME, Overexpression of connexin43 alters the mutant phenotype of midgestational wnt-1 null mice resulting in recovery of the midbrain and cerebellum. Anat Rec A Discov Mol Cell Evol Biol. 2005 Mar;283(1):224-38
1	J:119026 Morcillo J, Martinez-Morales JR, Trousse F, Fermin Y, Sowden JC, Bovolenta P, Proper patterning of the optic fissure requires the sequential activity of BMP7 and SHH. Development. 2006 Aug;133(16):3179-90
1*	J:175980 Mortensen AH, MacDonald JW, Ghosh D, Camper SA, Candidate genes for panhypopituitarism identified by gene expression profiling. Physiol Genomics. 2011 Oct 6;43(19):1105-16
1	J:143341 Omodei D, Acampora D, Mancuso P, Prakash N, Di Giovannantonio LG, Wurst W, Simeone A, Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon. Development. 2008 Oct;135(20):3459-70
1*	J:104488 Ozaki H, Nakamura K, Funahashi J, Ikeda K, Yamada G, Tokano H, Okamura HO, Kitamura K, Muto S, Kotaki H, Sudo K, Horai R, Iwakura Y, Kawakami K, Six1 controls patterning of the mouse otic vesicle. Development. 2004 Feb;131(3):551-62
1	J:188279 Peng C, Li N, Ng YK, Zhang J, Meier F, Theis FJ, Merkenschlager M, Chen W, Wurst W, Prakash N, A Unilateral Negative Feedback Loop Between miR-200 microRNAs and Sox2/E2F3 Controls Neural Progenitor Cell-Cycle Exit and Differentiation. J Neurosci. 2012 Sep 19;32(38):13292-13308
1	J:104370 Prakash N, Brodski C, Naserke T, Puelles E, Gogoi R, Hall A, Panhuysen M, Echevarria D, Sussel L, Weisenhorn DM, Martinez S, Arenas E, Simeone A, Wurst W, A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo. Development. 2006 Jan;133(1):89-98
1	J:83110 Puelles E, Acampora D, Lacroix E, Signore M, Annino A, Tuorto F, Filosa S, Corte G, Wurst W, Ang SL, Simeone A, Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain. Nat Neurosci. 2003 May;6(5):453-60
1	J:89367 Puelles E, Annino A, Tuorto F, Usiello A, Acampora D, Czerny T, Brodski C, Ang SL, Wurst W, Simeone A, Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain. Development. 2004 May;131(9):2037-48
1	J:79100 Riccomagno MM, Martinu L, Mulheisen M, Wu DK, Epstein DJ, Specification of the mammalian cochlea is dependent on Sonic hedgehog. Genes Dev. 2002 Sep 15;16(18):2365-78
1	J:174195 Saarimaki-Vire J, Alitalo A, Partanen J, Analysis of Cdh22 expression and function in the developing mouse brain. Dev Dyn. 2011 Aug;240(8):1989-2001
1	J:166617 Sakurai Y, Kurokawa D, Kiyonari H, Kajikawa E, Suda Y, Aizawa S, Otx2 and Otx1 protect diencephalon and mesencephalon from caudalization into metencephalon during early brain regionalization. Dev Biol. 2010 Nov 15;347(2):392-403
1	J:46806 Shekels LL, Hunninghake DA, Tisdale AS, Gipson IK, Kieliszewski M , Kozak CA , Ho SB, Cloning and characterization of mouse intestinal MUC3 mucin: 3' sequence contains epidermal-growth-factor-like domains. Biochem J. 1998 Mar 15;330(Pt 3):1301-8
1	J:198880 Shi M, Hu ZL, Zheng MH, Song NN, Huang Y, Zhao G, Han H, Ding YQ, Notch-Rbpj signaling is required for the development of noradrenergic neurons in the mouse locus coeruleus. J Cell Sci. 2012 Sep 15;125(Pt 18):4320-32
1*	J:2076 Simeone A, Acampora D, Gulisano M, Stornaiuolo A, Boncinelli E, Nested expression domains of four homeobox genes in developing rostral brain [see comments]. Nature. 1992 Aug 20;358(6388):687-90
1	J:104600 Trokovic R, Jukkola T, Saarimaki J, Peltopuro P, Naserke T, Weisenhorn DM, Trokovic N, Wurst W, Partanen J, Fgfr1-dependent boundary cells between developing mid- and hindbrain. Dev Biol. 2005 Feb 15;278(2):428-39
1	J:198684 Trowe MO, Zhao L, Weiss AC, Christoffels V, Epstein DJ, Kispert A, Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis. Development. 2013 Jun;140(11):2299-309
1	J:178971 Valenta T, Gay M, Steiner S, Draganova K, Zemke M, Hoffmans R, Cinelli P, Aguet M, Sommer L, Basler K, Probing transcription-specific outputs of beta-catenin in vivo. Genes Dev. 2011 Dec 15;25(24):2631-43
1*	J:85072 Vitelli F, Viola A, Morishima M, Pramparo T, Baldini A, Lindsay E, TBX1 is required for inner ear morphogenesis. Hum Mol Genet. 2003 Aug 15;12(16):2041-8
1*	J:42110 Wassarman KM, Lewandoski M, Campbell K, Joyner AL, Rubenstein JL , Martinez S , Martin GR, Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function. Development. 1997 Aug;124(15):2923-34
1	J:119950 Xu H, Viola A, Zhang Z, Gerken CP, Lindsay-Illingworth EA, Baldini A, Tbx1 regulates population, proliferation and cell fate determination of otic epithelial cells. Dev Biol. 2007 Feb 15;302(2):670-82
1	J:194842 Yang J, Brown A, Ellisor D, Paul E, Hagan N, Zervas M, Dynamic temporal requirement of Wnt1 in midbrain dopamine neuron development. Development. 2013 Mar;140(6):1342-52
1	J:243678 Zemke M, Draganova K, Klug A, Scholer A, Zurkirchen L, Gay MH, Cheng P, Koseki H, Valenta T, Schubeler D, Basler K, Sommer L, Loss of Ezh2 promotes a midbrain-to-forebrain identity switch by direct gene derepression and Wnt-dependent regulation. BMC Biol. 2015 Nov 30;13:103
1*	J:140027 Zou D, Erickson C, Kim EH, Jin D, Fritzsch B, Xu PX, Eya1 gene dosage critically affects the development of sensory epithelia in the mammalian inner ear. Hum Mol Genet. 2008 Nov 1;17(21):3340-56